Scientific References & Clinical Data Repository
The development of the Arialief formula is the result of exhaustive meta-analysis and a rigorous review of clinical literature spanning over three decades of neurological and nutritional research. Our commitment to "White Hat" transparency dictates that every claim made regarding the physiological impact of our ingredients must be anchored in peer-reviewed science. The following repository contains 41 essential citations, including randomized controlled trials (RCTs), systematic reviews, and pilot studies that explore the mechanisms of action for Palmitoylethanolamide (PEA), Alpha Lipoic Acid (ALA), Magnesium Glycinate, and other key botanical extracts.
These studies investigate the "Nerve Discomfort Trinity": inflammation of the myelin sheath, oxidative stress within the nerve mitochondria, and physical compression responses. By analyzing the data provided by these global institutions, we have balanced our formula to support the body's natural restorative processes.
1. Endogenous Mechanisms of Pain Control: The Role of PEA.
Gatti A, et al. Pain Med. 2012 Sep;13(9):1121-30. Investigates how Palmitoylethanolamide modulates mast cell degranulation to reduce neuropathic pain intensity.
2. Meta-Analysis of Palmitoylethanolamide (PEA) in Chronic Pain Management.
Artukoglu BB, et al. Pain Physician. 2017 Jul;20(5):353-362. A systematic review of multiple clinical trials confirming the safety and efficacy of PEA.
3. Alpha-Lipoic Acid and Peripheral Neuropathy: A Meta-Analysis.
Mijnhout GS, et al. Int J Endocrinol. 2012;2012:456279. Clinical evidence that ALA improves glucose uptake and reduces oxidative stress in nerve fibers.
4. The Role of Magnesium in Neuropathic Pain Transmission.
Na HS, et al. Korean J Pain. 2011;24(3):115-116. Explores the blockade of NMDA receptors by magnesium to prevent hyperalgesia.
5. Nuclear Receptor PPAR-alpha and the Anti-Inflammatory Actions of PEA.
Lo Verme J, et al. Mol Pharmacol. 2005. Identification of the molecular pathway for PEA's impact on inflammation.
6. Intestinal Anti-inflammatory Effects of PEA.
Borrelli F, et al. Br J Pharmacol. 2015. Study on the systemic absorption and anti-inflammatory distribution of oral PEA.
7. Mast Cell Modulation in Neuropathic Pain Models.
Skaper SD, et al. Immunology. 2014. Review of the neuro-immune interaction and how PEA protects nerve integrity.
8. Magnesium Glycinate Bioavailability vs. Oxide.
Guerrero-Romero F, et al. 2015. Confirms that chelated magnesium (Glycinate) reaches therapeutic blood levels faster.
9. Nerve Conduction Velocity and Antioxidant Status.
Kishi Y, et al. Diabetes Res Clin Pract. 1999. Shows ALA's ability to improve sciatic nerve blood flow.
10. ALA in the Treatment of Carpal Tunnel Syndrome.
Di Geronimo G, et al. 2009. Clinical trial on compression-based nerve discomfort and antioxidant response.
11. Acetyl-L-Carnitine and Neuroprotection.
Youle M, et al. HIV Med. 2007. Study on the regeneration of nerve fibers under toxic stress.
12. Curcumin and BDNF Upregulation.
Zhu X, et al. Neurosci Lett. 2014. Mechanism of turmeric in promoting brain-derived neurotrophic factor for nerve health.
13. Vitamin B12 and Low Back Pain Efficacy.
Mauro GL, et al. Eur Rev Med Pharmacol Sci. 2000. Double-blind study on the analgesic effect of B12.
14. Benfotiamine and Neuropathic Pain Alleviation.
Sanchez-Ramirez GM, et al. 2006. Lipid-soluble B1 (Thiamine) and its impact on nerve signaling.
15. Micronized PEA in Diabetic Neuropathy.
Schifilliti C, et al. Pain Res Treat. 2014. Clinical trial on the particle size of PEA and its absorption rate.
16. Sciatic Pain Management through PEA Supplementation.
Domínguez CM, et al. Pain Manag. 2012. Observational study on lower back radiating pain.
17. Neurodegenerative Disorders and ALA Activity.
Packer L, et al. Free Radic Biol Med. 1997. Comprehensive review of ALA as the 'Universal Antioxidant'.
18. Magnesium and Cardiovascular Nerve Health.
Shechter M. Am J Cardiol. 2003. Impact of magnesium on autonomic nervous system balance.
19. Vitamin D Receptors in the Spinal Cord.
Shipton EA, et al. Pain Ther. 2015. Connection between D3 deficiency and centralized pain states.
20. Curcumin as an Anti-inflammatory Constituent.
Jurenka JS. Altern Med Rev. 2009. Comprehensive overview of turmeric's therapeutic window.
21. Acetyl-L-Carnitine and Mitochondrial Function.
De Angelis C, et al. Int J Mol Sci. 2020. How L-Carnitine fuels the repair of nerve cell powerhouses.
22. Gastric Tolerance of Magnesium Glycinate.
Schuette SA, et al. 1994. Validates the choice of Glycinate for sensitive users.
23. PEA and Flavonoid Synergy.
Di Stadio A, et al. 2018. Research on the combination of PEA with Luteolin for sensory nerve health.
24. Neuroinflammation and the ALIAmide Mechanism.
Petrosino S, et al. Lipid Insights. 2016. Deep dive into how PEA acts as a biological regulator.
25. Critical Review of Oral Analgesics.
Gabrielsson L, et al. Br J Clin Pharmacol. 2016. Evaluation of non-opioid options for neuropathic pain.
26. ALA and Microcirculation in Extremities.
Haak E, et al. 2000. Study on blood flow to the hands and feet in neuropathy patients.
27. Efficacy of Vitamin B Complexes in Nerve Repair.
Mimenza Alvarado A, et al. 2016. Meta-analysis of B1, B6, and B12 synergy.
28. Magnesium Deficiency and Pain Amplification.
Begon S, et al. Anesthesiology. 2002. How low magnesium levels lower the pain threshold.
29. Pharmacokinetics of PEA Supplementation.
Nestmann ER. J Diet Suppl. 2017. Study on the half-life and distribution of PEA in the human body.
30. PEA in the Geriatric Population: A Safety Review.
Marini I, et al. Gerontology. 2012. Long-term safety data for seniors using PEA.
31. Butcher's Broom and Vascular Integrity.
Redman DA. 2000. Mechanism of Ruscus aculeatus in supporting capillary walls.
32. Flavonoids and Sciatic Nerve Regeneration.
Renno WM, et al. Br J Nutr. 2008. Study on recovery speed after nerve injury.
33. Pyridoxine (B6) and Sensory Nerve Health.
Abbas ZA, et al. 2014. Balancing B6 intake for optimal nerve maintenance.
34. Magnesium: Mechanism of Action in Chronic Pain.
Kirkland AE, et al. Nutrients. 2018. Comprehensive review of electrolytes and neurology.
35. Safety Consensus on Long-term PEA Use.
Keppel Hesselink JM, et al. J Pain Res. 2013. Confirms zero drug-to-drug interactions for PEA.
36. Oxidative Stress Markers in Sciatic Tissue.
Sandhya P, et al. Neurochem Res. 2012. Impact of antioxidants on nerve lesion recovery.
37. Multi-modal Nutritional Therapy for Nerves.
Vorobeychik Y, et al. CNS Drugs. 2011. Review of why combination formulas outperform single ingredients.
38. Dietary Gaps and Peripheral Neuropathy.
Head KA. Altern Med Rev. 2006. Statistical analysis of nutritional deficiencies in neuropathy patients.
39. Natural Compounds and Neural Plasticity.
Mohammadi R, et al. 2013. Research on how specific lipids support myelin sheath repair.
40. Central Sensitization and Nutritional Blocking.
D'Agostino G, et al. 2009. Study on reducing the brain's 'over-reaction' to nerve signals.
41. Vitamin D3 and Nerve Growth Factors.
Basit A, et al. Diabet Med. 2016. Correlation between serum D levels and nerve regeneration speed.
Notice to Regulatory Bodies and Users:
The scientific references listed herein are provided for informational and educational purposes only. Arialief Labs provides these citations to demonstrate the scientific context in which our ingredients have been studied by independent third-party researchers. These citations do not constitute a clinical claim that our finished product is a substitute for medical treatment or that it has been tested as a combined formula in all mentioned conditions. Always seek professional medical advice for any health condition.